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Legend (hyaluronate sodium) is an FDA approved I.V
Elevation in homocysteine is expected with cobalamin deficiency due to reduced methionine synthase activity even in the face of extreme cobalamin deficiency
Two downstream consequences are mechanistically central: nicotinamide is preserved for re-entry into the NAD+ salvage pathway (raising intracellular NAD+ availability), and SAM is preserved for other methylation reactions
It strengthens hair follicles and can even help with androgenetic alopecia
What we do know is that topical glutathione appears to work best as part of combination therapy
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