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Comparative studies indicate semaglutide producing a 15.8 percent mean weight loss at 68 weeks versus 6.4 percent with liraglutide, emphasizing its strong and sustained impact on weight management

195,196 Future research should elucidate the roles of SIRT1 in the microbiotaimmunemetabolism cross-pathways and evaluate its potential therapeutic synergy with microbiota-targeted interventions, including probiotics and dietary fibers