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The combined therapy of a swallowable weight-loss balloon and semaglutide oral formulation showed significant reductions in obesity-related comorbidities such as obstructive sleep apnea, type 2 diabetes, and hypertension in four months, according to a randomized, double-blind study in Obesity Surgery

However, patients should be advised to report symptoms suggestive of liver injury, including: Persistent nausea or vomiting unrelated to expected GI side effects Right upper quadrant abdominal pain (which may also indicate gallbladder disease, a known risk with GLP-1 therapy) Jaundice (yellowing of skin or eyes) Dark urine or pale stools Unexplained fatigue or malaise Clinicians should maintain a low threshold for investigating these symptoms with comprehensive liver function tests, including ALT, AST, alkaline phosphatase, bilirubin, albumin, and INR/prothrombin time

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Gastrointestinal issues such as nausea and constipation were the most frequent complaints, but in most cases they improved over time or were manageable with standard supportive care

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