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In a statement to Insider, Novo Nordisk, the company that makes Wegovy and Ozempic, said that Gila monsters and the discovery of exendin-4 "did not have anything to do with our decision to develop long-acting GLP-1 receptor agonists" for obesity, because "that was based on GLP-1 biology in humans." But the company also said that "the GLP-1-like effect of exendin-4" in Gila monsters was "an important contribution to the field," as it led to the development of the very first injectable drug of its kind
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In the pivotal STEP-1 trial, participants taking Wegovy lost an average of 14.9% of their body weight over 68 weeks
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TB-500, Actin Sequestration & Cell Migration TB-500, the synthetic fragment of Thymosin Beta-4, is studied primarily for its actin-binding properties
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