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They are highly toxic to the liver and are amongst the major identified risk factors for hepatocellular carcinoma 10,11,12
Amino Acids published online, doi:10.1007/s00726-010-0548-9 (16 March 2010)
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In other words, it is not a synthetic invention so much as a naturally occurring signaling molecule that researchers have tried to understand and, in places, to study therapeutically
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