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Drug interactions A number of cholesterol-lowering medications (like cholestyramine and colestipol), as well as orlistat, sucralfate, mineral oil, and the fat substitute olestra, which interfere with fat absorption, may theoretically decrease the absorption of fat-soluble vitamins, including vitamin E

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The reality is far more complex

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Some bioactivity can still be preserved if agitation was brief (under 5 seconds)