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Firstly, activated NF-B and NLRP3 inflammasome in DN promotes inflammation and increases fibronectin and collagen deposition in kidney, 41,42 leading to thickening glomerular basement membrane, glomerular sclerosis, podocyte damage, and ultimately kidney fibrosis

Mechanism of Action: A muscarinic agonist (producing no significant effect on nicotinic receptors)

Notably, most of these differentially expressed proteins were localized in the cytoplasmic, nuclear, and extracellular compartments (Fig

484 Cortes RiveraMMastronardiCSilva-AldanaCTArcos-BurgosMLidburyBA

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