whats the difference in tirzepatide and semaglutide or which is better vs. Semaglutide: What's Difference? Ozempic vs Tirzepatide: Choose the – Tirzepatide vs Semaglutide: Weight Loss,

Journal of Pharmacological Sciences , 65(4), 89-96

Colleen Ryan

Triple agonists add glucagon receptor activation, which: Increases resting energy expenditure by 8% to 12% (Jall et al., Diabetes Care 2024) Promotes hepatic fat oxidation and reduces steatosis May offset some of the lean mass loss seen with GLP-1 monotherapy (early signal, not yet confirmed in long-term trials) The weight loss ceiling for retatrutide appears to be 24% to 26% based on phase 3 data, though long-term real-world outcomes are not yet available

Additionally, patients report significant weight reductions, often 15 to 20 percent of body weight over 72 weeks

Great bedside manner