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Compared with the conventional chemical synthesis method, the method provided by the invention has the advantages of simple process, low cost and high yield, changes the characteristics of a solid phase carrier and increases the swelling performance of resin in a solvent by increasing the ionic liquid Linker and exchanging anions, thereby improving the coupling efficiency of amino acid residues synthesized by a solid phase, solving the hydrophobic characteristic of PS resin, avoiding the peptide chain aggregation in the process of peptide chain extension and further solving the problems of difficult residue solid phase coupling and low yield of the self sequence of the seraglutide caused by beta-folding
Methods Ethics statement The research described in this manuscript is compliant with all the relevant ethical regulations regarding animal research
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The name Retatrutide derives from ret (triple) and the standard GLP-1 agonist suffix
This article examines the current evidence, regulatory guidance, and appropriate monitoring strategies for patients and clinicians
