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doi:10.3390/ph17081081

It has been observed that adenoviral vectors that persist in the body are highly immunogenic and are responsible for strong CD8 T cellular and/or humoral immune responses specific to the transgenic antigen (85, 86)

But, this can change based on how bad the deficiency is and what each person needs

Nutrient deficiencies can occur as a result of eating nutrient-poor foods or foods with less bioavailable (easily and readily absorbed and used) nutrients, following a calorie-restricted diet, having inflammation from infections or food sensitivities , taking certain medications , or having an imbalance of gut bacteria