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While animal studies show a good safety profile, a theoretical risk involving its pro-angiogenic effects and potential cancer promotion is a point of consideration, though no evidence has supported this risk in practice

That is thought to be enough to reduce the risk of neural tube defects in pregnant women including those with MTHFR gene mutations

Because your skin may already be using potent actives, layering too many can cause irritation and paradoxically more pigment

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This isn't something to source online and self-administer