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This hormone plays a crucial role in: GLP-1 receptor agonists, like semaglutide (the active ingredient in Ozempic and Wegovy), mimic this hormone to amplify its effects

Mutations in genes that regulate the cell cycle and DNA repair further suggested mechanisms of increased CNAs: a truncating insertion in FGFR1OP, which anchors microtubules 47 (patient CAS-D) and deleterious missense mutations in WRN, associated with homology-directed repair and stability of fragile sites 48 , in patients CAS-C, CAS-F and MI-F

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2009;339:b2535