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This includes confirmed low serum vitamin B12 levels, pernicious anaemia, malabsorption states such as coeliac disease, inflammatory bowel disease, or post-gastric or bariatric surgery, unexplained anaemia, neuropathy or neurological symptoms consistent with vitamin B12 deficiency, a long-term vegan diet with symptoms or low levels, or failure of oral vitamin B12 supplementation

Benjamin Krasne, M.D

doi:10.1021/acs.jmedchem.7b00389

Long-term, supplemental, one-carbon metabolismrelated vitamin B use in relation to lung cancer risk in the vitamins and lifestyle (VITAL) cohort