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Given that the Rehan 2024 case was reported in a conference abstract with incomplete data, the agent unspecified, and causality unverifiable by independent assessment, this event is characterised as a reported temporal association rather than a confirmed causal relationship

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This was the first major setback, suggesting preclinical results might not translate to human disease

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GLP-1 agonists should not be used during pregnancy or breastfeeding, and effective contraception is advised for women of childbearing potential