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Therapeutic implications and future directions Currently, the available evidence demonstrates that region-specific BBB dysfunction including reduced CBF (shortfalls and dysregulations), impaired BBB integrity (increased BBB permeability and transport system), and vascular inflammation (extravasated plasma components and peri-vascular inflammatory responses) contributes to the onset and progression of multiple neurodegenerative disorders

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Mechanism 1

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We show below that the temperature dependent deviation from perfect Arrhenius kinetics can be fully accounted for by the diffusion properties of the lipids in the membrane and are hence solute independent