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Dosages in melatonin supplements range from 300mcg to 10 mg
Free from degradation, Nrf2 accumulates and translocates into the cell nucleus
However, the fact that AOXs are largely available over-the-counter with a reasonable price increases the risk that some patients can overmedicate with AOXs leading to detrimental effects
Understanding dose-response curves prevents under-dosing (inadequate receptor engagement) and over-dosing (wasteful without additional benefit, potentially increasing side effects)
Ethics declarations Conflict of interest Sun-Ki Kim, Managing Editor of Food Science and Biotechnology , was not involved in the editorial consideration of this manuscript
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