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By inhibiting STAT3, cancer cells can become more susceptible to anoikis, and simultaneously, a decrease in V-ATPase levels can lead to elevated reactive oxygen species and the accumulation of misfolded proteins within MDSCs [93]
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Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors
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