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The substituted cyclobutane Boc5, for example, is a small molecule GLP-1 receptor agonist that stimulates insulin secretion in vivo and reduces HbA1c levels and weight gain when delivered to db/db mice by chronic injection [21,22]
The table lists average weight loss of 14-17% for semaglutide at 2.4 mg and 20-22% for tirzepatide at 15 mg, with the article citing roughly 68 weeks of controlled trial follow-up
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