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Lean mass dropped by around 9.7%, but fat mass fell by 19.3%, and the proportion of lean mass in the body increased by about 3 percentage points
Conversely, those with lower-response markers benefit from progressing to 1.7 mg and potentially combining semaglutide with tirzepatide (a dual GLP-1/GIP agonist) for synergistic effect
The cause of this weight gain is unclear, as studies suggest that most people dont eat more after quitting smoking
2024b,c)
cons: possible confounding (people who are prescribed GLP-1 agents may differ in many ways), reverse causality, indication bias, duration of follow-up may be short for dementia (often slow developing)
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