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Significantly, of these, 6-phosphogluconate, glucose-6-phosphate, pentose-phosphate, and sedoheptulose-7-phosphate are generated in the pentose phosphate pathway (PPP), and are reported to be essential for redox maintenance and nucleic acid synthesis 28
Glutathione plays a pivotal role in most key physiological functions including but not limited to maintenance of cellular redox, neutralising free radicals, cell cycle regulation, proliferation, apoptosis, xenobiotic metabolism, and the recycling of other cellular antioxidants such as Vitamins C and E
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The binding of thrombin and other activated coagulant proteases to specific PARs, and the binding of fibrin to TLR-4 on inflammatory cells will further affect inflammation through release of proinflammatory cytokines and chemokines, which further modulates coagulation (101)
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