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According to the SmPC, no dose adjustment is required for patients with mild to moderate renal or hepatic impairment, as pharmacokinetic changes across these populations are not clinically relevant, but use is not recommended in cases of severe renal or hepatic impairment due to limited experience
& Suarez, D
A recent meta-analysis that included studies with tirzepatide, liraglutide, and exenatide showed that the medications reduced apnea events
Other medications falling within various drug classes, including additional GLP-1 receptor agonists, can serve as substitutes for semaglutide
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