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The findings indicated that over half of the patients experienced skin pigmentation without any reported adverse effects [157]

Patients who have highly reactive or barrier-impaired skin should introduce any new GHK-Cu copper peptide product gradually and avoid combining it with strong exfoliants, retinoids, or aggressive in-office treatments

The Yellow Card scheme: guidance for healthcare professionals, patients and the public

Anaesthesia 70 , 2937 (2015)

These effects are dose-dependent and tolerance develops within 714 days of consistent dosing, but starting too high causes protocol abandonment before pigmentation results become visible