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Its triple agonism opens an unprecedented axis on hepatic metabolism and lipid turnover that neither semaglutide nor tirzepatide cover
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This may explain why tirzepatide, despite producing greater weight loss than semaglutide, actually shows lower rates of nausea
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In comparison, no PK study indicated that the use of SGLT2 inhibitors could impact the required dose of levothyroxine to treat hypothyroidism
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