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The goal is decision support, not recommendation

In vitro , adequate Se concentrations decreased apoptosis and oxidative stress markers and increased proliferation and testosterone production of sheep Leydig cells by affecting p-ERK1/2 signaling, steroidogenic enzyme activities, and miR-200a/NRF antioxidant pathway (168)

These pharmacological agents demonstrate efficacy by simultaneously targeting multiple metabolic pathways

In practice, several additional clinical clues can help

For patients with diabetes at risk for anemia, Hennigar recommends considering the addition of an SGLT2 inhibitor to the medication regimen