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The median weight of participants was 85 kg (IQR: 7399), the median height was 163 cm (IQR: 158174), and the median BMI was 31.2 kg/m 2 (IQR: 27.635.8), suggesting a predominantly overweight or obese cohort
The first and most certain outcome is a catastrophic loss of potency
Time for returning to baseline LDL-C level might be slightly shorter using MEDI4166, around 10 and 14 days following a 1 mg/kg iv dose of MEDI4166 and anti-PCSK9 J16 mAb 42 respectively
E.et al (2010)
Medications with short half-lives may need to be taken several times a day
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