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The up-regulated gene list contained a number of glutathione depletionresponsive genes reported previously, such as Trib3, Srxn1, Myc, Asns, Igfbp1, Txnrd1, or Hmox1, suggesting that these genes are robust mRNA biomarkers for evaluating hepatic glutathione depletion

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Although the role of CD44 in the transport activity of xCT has not been validated so far, an interesting implication in iron endocytosis via CD44-bound hyaluronates is proposed (Figure 1)

However, the absence of follow-up studies limited the ability to conclude the effect on the disease progression

Professor Guido Schoenenberger of the University of Basel, one of the key scientists to have worked on DSIP, disagreed