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Their primary mechanisms of action include: Stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release , which reduces glucose production by the liver Slowing gastric emptying , which helps control post-meal blood sugar rises Reducing appetite through effects on brain centres that regulate hunger In the UK, GLP-1 receptor agonists are licensed for the treatment of type 2 diabetes mellitus and, in some cases, for weight management in adults with obesity or overweight with weight-related comorbidities
Mechanism of Action When GLP-1 peptides are administered, they bind to the GLP-1 receptors in the brain, pancreas, and gastrointestinal tract, leading to several key effects: Increased Insulin Secretion: Enhances insulin release in response to meals
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Mendelian randomization analysis also showed an inverse relationship between GLP-1 receptor expression and severe DR, indicating the potential of GLP-1RAs in reducing the risk of DR in type 2 diabetes patients (Zheng et al., 2023)
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