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Type 1 diabetic children initially exhibited lower RBC GSH concentrations compared to healthy subjects [129], and when those children were orally supplemented with vitamin E (100 IU/day) for 3 months, RBC GSH levels increased while lipid peroxidation and HbA1c levels decreased [129]
[29] [30] Metoclopramide should be limited to a maximum of 5 days due to risk of neurological adverse effects
Receptor agonist therapy offers targeted action, predictable dose responses, and potential reduction of adverse effects
This made it less practical for research designs that benefited from sustained or once-weekly exposure profiles
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