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Zhao Y, Wieman HL, Jacobs SR, Rathmell JC

It should be noted that these findings do not imply that DPP-4 inhibitors are harmful in any way or that GLP-1 drugs are definitely beneficial for brain health. Kornelius also noted that tirzepatide, a dual GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptor agonist, was not evaluated since it was approved after the beginning of the study period.

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Nevertheless, a conservative approach can be considered in patients who prefer not to progress to pharmacological therapy, provided that no major symptoms, such as hypoglycaemia leading to diminished awareness, coma or inability to drive or function, are present