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Stupnisek et al., 2015) (see Therapy of Bleeding Disorders as Support )

Trials typically incorporate biomarker endpoints such as ER/ER ratios, aromatase activity, plasma isoflavone or polyphenol concentrations, immune cell phenotyping, cytokine panels, oxidative stress markers and microbiome profile which are used to provide mechanistic read-outs of supplement activity and to inform patient stratification approaches (231)

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For compounds being administered to people with compromised immune systems, those impurities could include endotoxins, heavy metals, or degradation products

References 1 AbdelmegeedM