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Skinpen should not be used on patients who have active skin cancer in treatment areas, open wounds or sores, irritated skin in treatment areas, an allergy to stainless steel, any bleeding disorders, are pregnant or nursing, or are currently taking drugs with the ingredient isotretinoin (such as Accutane)

The expiration date on pharmaceutical products indicates the period during which the manufacturer guarantees full potency and stability under proper storage conditions

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The opioid-acetaminophen combination enhances the euphoric effects of opioids while also increasing the likelihood of prolonged use and dependence