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Zahreddine H, Borden KLB
In human thyroid cancer, GPx3 is frequently methylated, and the expression of GPx3 is regulated by methylation of the promoter region, and this methylation is related to tumor size and lymph node metastasis through the inhibition of Wnt/-catenin signaling [100]
These conditions do not absolutely prohibit semaglutide use but warrant thorough risk-benefit analysis, close monitoring, and potentially alternative treatment options
This means cagrilintide could theoretically combine with tirzepatide for even greater effects, though clinical data for this combination remains limited
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