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11,12 The 1990s introduced crucial discoveries in endoplasmic reticulum (ER) stress signaling and unfolded protein response (UPR) pathways, establishing ER proteostasis as a cornerstone of metabolic and neurodegenerative disease biology
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Because the molecule tested was the same tirzepatide now marketed as Zepbound, these diabetes-focused results also inform our understanding of tirzepatide's metabolic effects across indications
The authors stated that the peptide had the effect of increasing melatonin concentration in the test subjects, thus contributing to enhanced control of the sleepwake cycle [6]
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