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therefore, both peptides can lead to increased skin pigmentation and tanning [1, 9, 10]
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Retatrutide, a GIP, GLP-1, and Glucagon Receptor Agonist, for People with Type 2 Diabetes: A Randomised, Double-Blind, Placebo-Controlled, Phase 2 Trial. The New England Journal of Medicine
GLP-1R agonism has well-established actions to reduce glucagon secretion in both isolated human islets 28 and in vivo 29 , whereas GIPR agonism increases glucagon secretion in preclinical models 11 and in humans 30
