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For a population of people with type 2 diabetes and first-time GLP-1 RA prescriptions, we found decreases in baseline A1C and BMI values (prior to GLP-1 RA initiation) between January 2020 and November 2023

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When a low dose of aspirin is administered orally (most commonly 81 mg), its context-sensitive drug disposition via the portal circulation combined with the difference in IC50 values for COX-1 vs COX-2 both contribute significantly to the high selectivity by which low dose oral aspirin inhibits platelet COX-1 vs other COX-2 found in other nucleated tissues such as the vascular endothelium (Pedersen & FitzGerald, 1984

While these findings suggest a potential protective association, the observational nature of this study precludes definitive conclusions regarding causality

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