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I don't see how you are getting that only 5mcg is lost daily: if you have injected say 1000 mcg of B12, most of it is peed out within a few days

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These elevated ROS levels can, in turn, further disrupt sleep patterns, creating a vicious cycle

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Oral supplements must first pass through the digestive tract, where a portion of the active compound can be degraded or poorly absorbed, especially if gastrointestinal issues are present

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Nature 491 , 364373 (2012)

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Signaling functions of reactive oxygen species

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