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Together with findings from SELECT [18], these data suggest that GLP-1-based therapies may exert renoprotective effects that are not contingent on glycemic modulation, expanding their potential relevance across metabolic phenotypes
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Felix Beuschlein has received financial support for attending symposia and for educational programmes by Novo Nordisk
In the peripheral system, GLP-1R mediates the actions of GLP-1 via the incretin axis, in which stimulation of the GLP-1R with GLP-1 primarily triggers insulin release from islet cells in a glucose-dependent manner and inhibits glucagon secretion from islet cells (110)
Because the prescription GLP-1s actually bind to and activate GLP-1 receptors, it has been difficult to replicate these effects orally with a plant extract, herbal compound, or probiotic. However, several oral GLP-1 pills are available, including Ozempic, Wegovy and Foundayo
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