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NAPQI can be detoxified by subsequent phase II metabolism via conjugation with glutathione (GSH), partly mediated by different glutathione S -transferase (GST) isozymes (Figure 1) (Mitchell et al., 1973b)
Neither route has human clinical trial evidence
If you find yourself getting sick more often than usual or having allergies where you previously had none, you may need a B12 shot
Rare side effects include headache (4-6%), transient diarrhea (3-4%), and acne flare (2-3%)
Community sources describe shortened effective windows (5-14 days rather than 28) when post-puncture storage exceeds 30C consistently
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