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NAC can be an effective way to boost glutathione levels but is not the only way

This precursor approach is largely self-regulating

A person can carry an MTHFR or COMT variant and still have adequate current methylation, while another person with no major variant can develop low SAM, elevated SAH or impaired glutathione production

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If your diet does not provide B12 vitamins at all typical of those on a vegetarian or vegan diet you may need to take B12 tablets for the rest of your life