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88 STAT3 forms complexes with TOX, directly binding promoters of inhibitory receptors such as PD-1, TIM-3, and LAG-3, increasing chromatin accessibility and enforcing an exhausted phenotype

Complications of Statin Therapies Although the use of statin class drugs have proven effective at preventing cardiovascular disease, these drugs are not without potentially severe negative outcomes

10.7326/AITC202105180 124 McGirtM

This upregulation enhances resting energy expenditure and promotes the oxidation of adipose tissue