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3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium 36

Gradual dose titration, structured nutritional guidance, symptom monitoring, and early imaging when indicated are effective strategies to reduce complications while maintaining metabolic benefit

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Moreover, sex-dependent differences in the effects of GLP-1 receptor agonists have been reported clinically, with some evidence suggesting greater weight-loss responses and potentially different pharmacokinetic profiles in women and men (Yang et al., 2025), whereas preclinical studies have shown stronger suppression of alcohol self-administration and reinstatement in males, with females exhibiting less pronounced behavioral effects (Daz-Megido and Thomsen, 2023)