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That concern came up directly, and it is a fair question

This biphasic dose-response curve means higher concentrations do not produce proportionally greater anti-inflammatory effects and may reverse therapeutic benefits

Important safety considerations include risk of pancreatitis (treatment should be discontinued if suspected), gallbladder disease, and potential worsening of diabetic retinopathy in patients with pre-existing retinopathy who experience rapid improvement in glucose control (particularly with semaglutide)

Molecular Carcinogenesis, 54 (10), 1096-1109

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