long term use of bpc 157 BPC-157: What It Is, What We Know, and Why Its for Arthritis Remains Unproven The Hidden Risks of BPC‑157:

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Intranasal (IN): IN administration has gained significant research interest for CNS-targeted peptide studies because it provides a direct pathway to the brain via the olfactory and trigeminal nerve pathways, bypassing the blood-brain barrier (BBB)

NZMJ 10:1436 Tuba-Kartal A, ala-Mutlu Z (2020) Comparison of sublingual and intramuscular administration of vitamin B12 for the treatment of vitamin B12 deficiency in children

The rationale for combining them is mechanistic complementarity

Many peptides are not approved by regulators, and their safety, purity, and interactions are not well established