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Why GHK-Cu levels matter Research published in PMC (National Institutes of Health) documents the age-related decline in GHK plasma levels clearly: concentrations of approximately 200 ng/mL at age 20 drop to around 80 ng/mL by age 60 a decline of more than 60%
This broader hormonal footprint is well documented in the pharmacology literature and is one of the main scientific reasons more selective secretagogues were subsequently developed
While effective for immediate symptom resolution, this approach shuts down endogenous production by triggering a negative feedback loop
The hydroxyl radical is especially notorious for causing DNA damage
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