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Liver-related observations also require context

Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: In vivo and in vitro evidence

Samples were embedded in PBS on microscopic glass slides and imaged directly

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Although direct assessment of spermatogenesis using histomorphometric indices (e.g., Johnsen score) was not conducted, the observed decline in sperm parameters and the histological disruption of germinal epithelium indirectly reflect compromised spermatogenic activity