For hormonally-driven conditions like melasma, maintenance is key, as hormonal shifts can trigger new discoloration
But this remains difficult to prove in humans
Allergic reactions are uncommon, but if you were to experience symptoms like swelling of the tongue or throat, hives, or difficulty breathing after an injection, that could indicate an allergy and you should seek medical help immediately
Based on these data, an ongoing phase 1/2a, multicenter, open-label, ascending dose, first in-human clinical trial is planned to evaluate the safety of intracisternal PR001A (AAV9-GBA1) administration in patients with moderate to severe PD with at least one GBA pathogenic variant (NCT04127578, Table 2)
Nutrients 4 : 13991440 (2012)