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(2024) 15:e0203223
doi: 10.1212/CON.0000000000000668 [PubMed] LaRoche, S
The ice and press technique Apply a clean ice cube to the injection site for 30 seconds
ATPase activity assays confirmed that coumarin stimulates ATP hydrolysis by P-glycoprotein (P-gp), indicating that coumarin acts as a substrate for it, and the nanoparticles were shown to inhibit P-gp-mediated efflux, enhancing drug retention in cells
The absolute dosing regardless of body mass likely increased the variability of response within supplementation groups thereby limiting the findings of the present study
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