To explore the reasons for permanent discontinuation of tirzepatide controls [placebo, insulin, and glucagon-like peptide-1 receptor agonists (GLP-1Ras)] in RCTs
Key takeaways Leg cramps can occur for various reasons, such as nerve dysfunction and health conditions, including diabetes and kidney failure
Of the 286 AE reports with available information on age, the median age of patients was 56 years [interquartile range (IQR) = 4867]
GLP-1s offer significant promise to millions of Americans living with obesity, diabetes and/or cardiovascular disease, but their unprecedented demand and high price tags are creating challenging downstream impacts, including fluctuating supply, inconsistent clinical support, and runaway cost trajectory, said an Evernorth statement
The findings demonstrated that Semaglutide produces clinically meaningful and sustained weight loss, and most importantly, provides cardiovascular benefits irrespective of the amount of weight lost, highlighting its broad impact on metabolic health