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The cardiovascular safety of this dose of semaglutide is currently being evaluated in the SELECT trial, where 17,500 individuals with obesity and established CVD are randomised to semaglutide or placebo for 2.5-5 years

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Selecting this reduces calculated BMR by 5%

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NICE guidance (NG238) does not currently recommend GLP-1 receptor agonists specifically for dyslipidaemia treatment, though their cardiovascular benefits are recognised in appropriate patient populations

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