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Typical descriptions: "Day 3 was when I really noticed," "By Thursday (injected Monday) I felt like a different person." Days 4-7: Plateau phase

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We ensure our patients receive the proper dosage for the appropriate length of time

This reactive transformation entails morphological, functional and transcriptional remodeling, forming a continuum of activation states ranging from transient, protective responses to chronic, neurotoxic phenotypes

84 Chronic T-cell receptor (TCR) signaling and sustained antigen exposure contribute to CD8 T-cell senescence, functional paralysis, and eventual deletion, which are hallmarks of acquired resistance